Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs Hypothesis
Pathology
Indications
Methods
Diagnostic Materials
Measurements
Multimodal Cell Analysis
Quality Control
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Biological background of diagnostic DNA-ICM

 
The following biological phenomena affect the DNA-content of cell-nuclei:
 
Proliferation and thus different
Cell cycle phases
Euploid polyploidisation
Chromosomal aneuploidy
 
Mutations of genes do not affect nuclear measurable DNA content
 
DNA-histogram of normal diploid thyroid epithelial cells (red) with G0/1-phase peak, comprising 92% and proliferation fraction, comprising 8% of cells.. Normal diploid lymphocytes (blue) as internal reference cells
 
 
 
 
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What affects nuclear
DNA-content?