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You are here Background | Duesbergs/Rasnick Hypothesis
   

The chromosomal theory of carcinogenesis of Bovery and von Hansemann

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D. von Hansemann (1890) recorded mitotic chaos in carcinoma cells
and postulated that this was the cause of cancer
 
T. Bovery (1902, 1914) suggested that aberrant chromosomes numbers (aneuploidy) may cause cancer. But he did not suggest a detailed mechanism
 
Until 50 years ago many scientists regarded chromosomal aberrations
as the cause of cancer
 
 
 
Theodor Boveri speculated in 1902
 
that multipolar mitosis cause aneuploidy and might under certain conditions
lead to the development of tumour-like formations:
 
 
 
 
Typical (left) and atypical mitosis (right) in HPV-infected oral squamous epithelium
 
 
 
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The aneuploidy hypothesis
of carcinogenesis
is 100 years old

 


 

 
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Atypical mitoses
are the cytologic equivalent
of chromosomal aneuploidy