Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs/Rasnick Hypothesis
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You are here Background | Duesbergs/Rasnick Hypothesis
   
The aneuploidy-theory of carcinogenesis
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All malignant cells reveal chromosomal aneuploidies
 
Specific aneuploid karyotypes are the cause of malignant cell transformations
 
Clonal aneuploidy in proliferating cells (stemlines) is the crucial pathogenetic step
of malignant transformation
 
(Duesberg et al., 1999, 2004, 2005, 2007)
 
P. Duesberg and D. Rasnick organized the 1st international
conference on aneuploidy and cancer in 2004.
 

The aneuploidy theory of carcinogenesis

 
Carcinogenes and spontaneous mitotic errors cause unspecific chromosomal aneuploidies
 
Aneuploidy destabilises the karyotype because it influences thousands of genes, that change
thousands of proteins, that help to synthesize, separate, repair and regularly distribute
chromosomes
 
Aneuploidy may result in cell death (apoptosis) or malignant transformation
 
The higher the grade of chromosomal aneuploidy, the higher the karyotypic
instability of a cell
 
Apoptosis of an HPV-infected squamous cell
from the oral mucosa
  Malignant squamous cell in an oral HPV-infected mucosa, revealing atypical mitosis
 
 
 
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Mutations may set cells at risk for subsequent
chromosomal aneu-ploidy

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Carcinogenes
ultimately
cause aneuploidy