Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs/Rasnick Hypothesis
Pathology
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You are here Background | Duesbergs/Rasnick Hypothesis
   
Many influences may cause chromosomal aneuploidy
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Heredetary chromosomal repair defects (e.g. Fanconi anemia)
Herdetary hyperplasia-syndromes (MEN I & II)
Ionozing radiation (e.g. x-rays)
Viral infections (e.g. HPV)
Chemical agents (e.g. nitrosamines)
Mechanical forces (asbestos fibres)
Mutation of certain genes (e.g. APC)
Hypomethylation of DNA (e.g. bladder cancer)
 
Premalignant oral mucosa in a patient with Fanconi anemia who later
developed cancer
 
Carcinogenes cause aneuploidy
 
According to the current theory, carcinogenes should be mutagenes, yet:
 
Half of carcinogenes do not cause mutations
(asbestos, tar, aromatic hydrocarbons, vinylchoride, urethane, dioxine)
 
The radiation dose required to cause chromosomal aneuploidy
is 1000x lower than that to cause a mutation
 
The fraction of aneuploid cells that becomes neoplastic is, however, very low
 
The chromosomes of cells, treated with carcinogenes become instable and thus aneuploid
 
Asbestos body (brown) containing asbestos fibre (invisible)
in a macrophage in a bronchial secretion of an asbestos worker
 
Many influences may cause chromosomal aneuploidy
 
For example, migration of chromosomes is disturbed by asbestos fibres
in cell culture
 
Asbestos fibres have physical properties to break chromosomes during mitosis
 
Anaphase of a human cell in culture. Chromosomal segregation is disturbed
by asbestos fibres
 
 
 
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Whole chromosomes
or their parts are lost
or gained in aneuploidy

 

 

 

 

 

 

 

 

 

 



 

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Carcinogenes cause chromosomal aneuploidy

 

 

 

 

 

 

 

 

 

 

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Asbestos fibres may hurt chromosomes
during cell division

 
 

 

 

 

 

   
     
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