Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs/Rasnick Hypothesis
Pathology
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Methods
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Multimodal Cell Analysis
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You are here Background | Duesbergs/Rasnick Hypothesis
   
X-rays cause chromsosomal aneuploidy in cell culture even at low doses
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Mechanisms of aneuploidisation
 
Dysfunctions of the following organelles, structures or proteins that contribute
to the regular doubling of chromosomal sets, may cause aneuploidy:
 
centromeres
centrioles
centrosomes (e.g. CDK2)
telomeres
spindle fibres
spindle-checkpoints (SCP, BubR1)
repair of doublestrand breakages
 
Regular (left) and irregular mitosis (right) in oral squamous epithelium, caused by
interaction of viral oncoproteins with spindle fibres
 
Possible effects of chromosomal aneuploidy
 
Mitotic stop
Cell death (apoptosis)
Immortalisation
Neoplastic transformation
Resistance to chemotherapy
 
Apoptosis (programmed cell death) of an HPV-infected squamous cell
of the oral mucosa
 
 
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Low-dose radiation may cause chromosomal aneuploidy and thus cancer

 


 

 

 

 

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Regular mitosis can be disturbed at many cellular levels

 
 




 

 

 

 

 

 

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Cancer is caused
by disturbed number
of chromosomes
or their parts

 
 

 

 

 

 

 

     
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