Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs/Rasnick Hypothesis
Pathology
Indications
Methods
Diagnostic Materials
Measurements
Multimodal Cell Analysis
Quality Control
Diagnostic Interpretation
Diagnostic Applications
Case Reports
Responsabilities
References
Terminology
Abbreviations
Contact
Sitemap
1 2 3 4 5 6 7 8 9 10 11 12
   
You are here Background | Duesbergs/Rasnick Hypothesis
   

The effects of chromosomal aneuploidy

spacer
Chromosomal aneuploidy causes dysfunctionality or apoptosis of affected cells
 
Cancer specific karyotypes generate cancer specific phenotypes, independent from mutations
 
This effect on the phenotype of cancer-tissue, caused by imbalance and dysregulation of about 1000 proteins is similar to Down-syndrome in which an extra chromsome no. 21 causes many phenotypical abnormalities of the whole human body
 
Normal karyotype Karyotype with trisomy 21
(Downs-syndrome)
 
 
 
 
-

Additional chromosomes
result in additional
proteins