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You are here Background | Duesbergs/Rasnick Hypothesis
   

Evidence for the chromosomal theory of carcinogenesis

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More and more clonal marker-chromosomes were discovered since the Philadelphia chromosome in 1960
 
All solid cancers investigated so far, revealed chromosomal aneuploidy
 
Clinical experience demonstrates: grades of malignancy are proportional to degree of aneuploidy
 
Normal human karyotype Karyotype of a renal cancer cell with numerical and structural chromosomal aberrations: trisomies 5, 7 16, del 3
and missing X or Y
 
 
Many tumours share specific primary numerical chromosomal aberrations
 
Colorectal carcinoma +7; -17; -18; up to 75%
Bronchial carcinoma -Y; -22; up to 100%
Breast cancer +7, +8, +20 -13; -X; frequently
Ovarian cancer +1; +2; +3; +6; +7; +9; +12; +20; -4; -8; -11;
-13, -14, -15, -17; -22; frequently
Prostate cancer +7; -Y; frequently
 
AML +8; -7; 10 – 15%
ALL +4; +6; +10; +14; +18; +21; up to 30%
CML +8; +17; +19; +21; in Blast crisis
Multiple Myeloma +3; +5; +7; +9; +11; +15; +19; + 21; up to 66%
Non-Hodgkin-Lymphomas +3; +5; +7; +8; +11; +12; +18; -13; -14; -15;up to 20%
 
 
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Cancer cells are aneuploid

 

 

 

 

 

 
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Primary chromosomal aberrations mostly are tumour type specific