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You are here Background | Duesbergs/Rasnick Hypothesis
   

The chromosomal theory of carcinogenesis
by Peter Duesberg and David Rasnick (1999, 2004, 2005, 2007)

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Malignant transformation is the result of a chain reaction
of multiple chromosomal aneuploidisations
 
It starts with a crucial chromosomal aberration that triggers further ones
(genetic instability)
 
Number of chromosomal aberrations increases with time (tumour progression)
 
Grade of tumor malignancy increases with number of chromosomal aberrations
 
 
 
Multistep-carcinogenesis represents a chain-reaction of multiple aneuploidisations
 
 
P. Duesberg et al., 1999, 2004, 2005, 2007
 
 
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The Duesberg/Rasnick aneuploidy hypothesis of carcinogenesis

 

 

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The caryotype of cancer cells mostly changes over time