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You are here Background | Polyploidy
   
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Euploid polyploidisation
including tetraploidy, octoploidy etc.
 
Chromosomal
Chromosomal set that results from repeated doublings
of a single chromosomal set
 
DNA-cytometric
Frequency peaks at integer valued multiples of 2c (e. g. 4c, 8c, 16c, 32c)
 
Chromosomal Set of a normal human male tetraploid cell showing
92 chromosomes
 
 
Euploid polyploidisation in humans
is caused by: (Biesterfeld et al., 1994)
Increased functional demand (liver, heart, skeletal muscle ) Ionising radiation
Enforced regeneration   Cytostatic agents
Viral infections (HPV)   Vitamin B12-deficiency
     
Euploid polyploidisation
was described in (Biesterfeld et al., 1994)
Thyreocytes Adrenal cells
Bronchial mucosa cells   Urothelial cells
Myocardial cells   Endocervical cells
Mesothelial cells   Decidual cells
Hepatocytes   Trophoblastic cells
Striated muscle cells   Seminal vesicle epithelium
    Megacaryocytes
 
Euploid polyploidisation results in modal DNA-values at doubling positions
of normal diploid cells within their 95 % confidence-intervals
 
 
DNA-euploid-polyploidy in HPV-infection of the uterine cervix,
revealing stemlines at 2c and 4c, but no cells > 9c
 
 
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Euploid polyploidisation
frequently occurs
in benign human cells

 


 
   
   
   
     
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