Repeated doubling of cells by division and thus geometric multiplication of their numbers (= mitosis, R. Virchow, 1900).
is associated with repeated doublings of chromosome sets and of nuclear DNA-content.
Those fraction of the cell cycle in which DNA-synthesis (S-), growth-arrest
(G2-) and mitosis (M-) occur.
Proliferation-rate (PR) is the proportion of proliferating cells in a population.
Proliferation-rate correlates with malignant potential of tumours.
DNA-histogram of normal diploid thyroid epithelial cells (red) with G0/1-phase peak, comprising 92% and proliferation fraction, comprising 8% of cells.. Normal diploid lymphocytes (blue) as internal reference cells
Nuclear DNA-content changes with