Introduction
Background
Proliferation
Cell Cycle
Mutations
Euploidy
Polyploidy
Aneuploidy
Duesbergs Hypothesis
Pathology
Indications
Methods
Diagnostic Materials
Measurements
Multimodal Cell Analysis
Quality Control
Diagnostic Interpretation
Diagnostic Applications
Case Reports
Responsabilities
References
Terminology
Abbreviations
Contact
Sitemap
1 2 3
   
You are here Background | Proliferation
   
 

Proliferation

spacer
Repeated doubling of cells by division and thus geometric multiplication of their numbers (= mitosis, R. Virchow, 1900).

is associated with repeated doublings of chromosome sets and of nuclear DNA-content.

 
Proliferation-phase
 
Those fraction of the cell cycle in which DNA-synthesis (S-), growth-arrest
(G2-) and mitosis (M-) occur
.

Proliferation-rate (PR) is the proportion of proliferating cells in a population.

Proliferation-rate correlates with malignant potential of tumours.

 
DNA-histogram of normal diploid thyroid epithelial cells (red) with G0/1-phase peak, comprising 92% and proliferation fraction, comprising 8% of cells.. Normal diploid lymphocytes (blue) as internal reference cells
 
 
 
-

Nuclear DNA-content changes with
cell-cycle-phases