Introduction
Aims of Tutorial
Instructions to Use
History of DNA-ICM
Background
Pathology
Indications
Methods
Diagnostic Materials
Measurements
Multimodal Cell Analysis
Quality Control
Diagnostic Interpretation
Diagnostic Applications
Case Reports
Responsabilities
References
Terminology
Abbreviations
Contact
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Diagnostic DNA-ICM is used
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to assist in the early microscopical diagnosis and grading of various types of tumors, measuring the DNA-contents of their cells
 
Diagnostic DNA-ICM works by
determination of nuclear DNA-contents, deposited on glass slides and specifically stained on images by measurements of their integrated optical densities (IODs).
 
Diagnostic DNA-ICM requires
a microscope equiped with a video- or CCD-camera, a personal computer equiped with a specific application software for densitometric image analysis and diagnostic data-interpretation and cells from a suspicious lesion of the human body on glass slides, specifically stained for DNA
 
Diagnostic DNA-ICM is based on
chromosomal aneuploidy
a specific marker for tumor cells
DNA-aneuploidy
the cytometric equivalent of chromosomal aneuploidy
a sensitive and specific marker for tumor cells
that is derived from DNA-histograms
 
 
 
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You need
1. Microscope
2. CCD-camera
3. Standard-PC
4. Application-Software 5. Cells on glass slides